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數十年的研究不端行為延誤阿茲海默症療法突破 (★ 104 分)

這篇文章揭露多年來在阿茲海默症研究中,圍繞著「澱粉樣蛋白假說」所展開的資料造假與學術不端問題。文章起始於 2021 年 12 月,一位具資歷的吹哨者提供關鍵證據,指出多項實驗資料可能為虛假資料,此一爆料在 2022 年 7 月於 Science 雜誌公布後便引起國際關注。隨後,兩家大型製藥公司宣布一項突破性進展,推出名為 Leqembi 的藥物,宣稱該藥能從腦組織中清除澱粉樣蛋白斑塊,藉此印證長期爭議的假說,但實際上該藥僅略微改善患者症狀,效果微乎其微。

文章進一步探討,歷年來主流的澱粉樣蛋白假說使得其他治療途徑被邊緣化,導致政府、製藥公司以及慈善團體的龐大經費投入未能帶來真正有效的治療方案。調查記者查爾斯·皮勒揭露了科學界內部因傲慢、貪婪及研究不端行為所造成的一連串失敗,最終讓眾多患者及其家屬陷入深深絕望與沉重經濟負擔,真正有效的療法因此遙遙無期。

👥 31 則討論、評論 💬
https://news.ycombinator.com/item?id=43151320



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數十年的研究不端行為延誤阿茲海默症療法突破 (★ 104 分)

這篇文章揭露多年來在阿茲海默症研究中,圍繞著「澱粉樣蛋白假說」所展開的資料造假與學術不端問題。文章起始於 2021 年 12 月,一位具資歷的吹哨者提供關鍵證據,指出多項實驗資料可能為虛假資料,此一爆料在 2022 年 7 月於 Science 雜誌公布後便引起國際關注。隨後,兩家大型製藥公司宣布一項突破性進展,推出名為 Leqembi 的藥物,宣稱該藥能從腦組織中清除澱粉樣蛋白斑塊,藉此印證長期爭議的假說,但實際上該藥僅略微改善患者症狀,效果微乎其微。

文章進一步探討,歷年來主流的澱粉樣蛋白假說使得其他治療途徑被邊緣化,導致政府、製藥公司以及慈善團體的龐大經費投入未能帶來真正有效的治療方案。調查記者查爾斯·皮勒揭露了科學界內部因傲慢、貪婪及研究不端行為所造成的一連串失敗,最終讓眾多患者及其家屬陷入深深絕望與沉重經濟負擔,真正有效的療法因此遙遙無期。

👥 31 則討論、評論 💬
https://news.ycombinator.com/item?id=43151320

BY Hacker News 100 繁體中文




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Official government accounts have also spread fake fact checks. An official Twitter account for the Russia diplomatic mission in Geneva shared a fake debunking video claiming without evidence that "Western and Ukrainian media are creating thousands of fake news on Russia every day." The video, which has amassed almost 30,000 views, offered a "how-to" spot misinformation. A Russian Telegram channel with over 700,000 followers is spreading disinformation about Russia's invasion of Ukraine under the guise of providing "objective information" and fact-checking fake news. Its influence extends beyond the platform, with major Russian publications, government officials, and journalists citing the page's posts. "The argument from Telegram is, 'You should trust us because we tell you that we're trustworthy,'" Maréchal said. "It's really in the eye of the beholder whether that's something you want to buy into." On February 27th, Durov posted that Channels were becoming a source of unverified information and that the company lacks the ability to check on their veracity. He urged users to be mistrustful of the things shared on Channels, and initially threatened to block the feature in the countries involved for the length of the war, saying that he didn’t want Telegram to be used to aggravate conflict or incite ethnic hatred. He did, however, walk back this plan when it became clear that they had also become a vital communications tool for Ukrainian officials and citizens to help coordinate their resistance and evacuations. Andrey, a Russian entrepreneur living in Brazil who, fearing retaliation, asked that NPR not use his last name, said Telegram has become one of the few places Russians can access independent news about the war.
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