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⚠️ ام‌پاکس آبله میمون MPox Monkeypox

⚠️ ام‌پاکس آبله میمون MPox Monkeypox

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MVA-BN vaccination generated mpox antibodies that waned by 6 to 12 months. In participants who received 2 doses of MVA-BN vaccine, mpox antibody responses at 12 months were comparable to or lower than peak antibody responses in people receiving 1 dose, which provided limited protection.2 Serum antibody titers after vaccination have been shown to correlate with protection against mpox challenge in nonhuman primates.3,6 Moreover, a cluster of mpox infections was reported in 2023 in vaccinated humans with waning immunity.5 These data suggest that protective immunity may be waning in individuals who were vaccinated with MVA-BN in 2022 and that boosting may be required to maintain robust levels of protective immunity. Study limitations include its small sample size, convenience sample, and observational design. Larger studies are needed to confirm generalizability and to assess vaccine effectiveness over time.

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Create: 2024-10-04
Last Update: 2025-02-27 13:00:27

MVA-BN vaccination generated mpox antibodies that waned by 6 to 12 months. In participants who received 2 doses of MVA-BN vaccine, mpox antibody responses at 12 months were comparable to or lower than peak antibody responses in people receiving 1 dose, which provided limited protection.2 Serum antibody titers after vaccination have been shown to correlate with protection against mpox challenge in nonhuman primates.3,6 Moreover, a cluster of mpox infections was reported in 2023 in vaccinated humans with waning immunity.5 These data suggest that protective immunity may be waning in individuals who were vaccinated with MVA-BN in 2022 and that boosting may be required to maintain robust levels of protective immunity. Study limitations include its small sample size, convenience sample, and observational design. Larger studies are needed to confirm generalizability and to assess vaccine effectiveness over time.

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Date: 2025-02-27|

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