MVA-BN vaccination generated mpox antibodies that waned by 6 to 12 months. In participants who received 2 doses of MVA-BN vaccine, mpox antibody responses at 12 months were comparable to or lower than peak antibody responses in people receiving 1 dose, which provided limited protection.2 Serum antibody titers after vaccination have been shown to correlate with protection against mpox challenge in nonhuman primates.3,6 Moreover, a cluster of mpox infections was reported in 2023 in vaccinated humans with waning immunity.5 These data suggest that protective immunity may be waning in individuals who were vaccinated with MVA-BN in 2022 and that boosting may be required to maintain robust levels of protective immunity. Study limitations include its small sample size, convenience sample, and observational design. Larger studies are needed to confirm generalizability and to assess vaccine effectiveness over time.
MVA-BN vaccination generated mpox antibodies that waned by 6 to 12 months. In participants who received 2 doses of MVA-BN vaccine, mpox antibody responses at 12 months were comparable to or lower than peak antibody responses in people receiving 1 dose, which provided limited protection.2 Serum antibody titers after vaccination have been shown to correlate with protection against mpox challenge in nonhuman primates.3,6 Moreover, a cluster of mpox infections was reported in 2023 in vaccinated humans with waning immunity.5 These data suggest that protective immunity may be waning in individuals who were vaccinated with MVA-BN in 2022 and that boosting may be required to maintain robust levels of protective immunity. Study limitations include its small sample size, convenience sample, and observational design. Larger studies are needed to confirm generalizability and to assess vaccine effectiveness over time.
This ability to mix the public and the private, as well as the ability to use bots to engage with users has proved to be problematic. In early 2021, a database selling phone numbers pulled from Facebook was selling numbers for $20 per lookup. Similarly, security researchers found a network of deepfake bots on the platform that were generating images of people submitted by users to create non-consensual imagery, some of which involved children. Telegram was co-founded by Pavel and Nikolai Durov, the brothers who had previously created VKontakte. VK is Russia’s equivalent of Facebook, a social network used for public and private messaging, audio and video sharing as well as online gaming. In January, SimpleWeb reported that VK was Russia’s fourth most-visited website, after Yandex, YouTube and Google’s Russian-language homepage. In 2016, Forbes’ Michael Solomon described Pavel Durov (pictured, below) as the “Mark Zuckerberg of Russia.” Sebi said data, emails and other documents are being retrieved from the seized devices and detailed investigation is in progress. One thing that Telegram now offers to all users is the ability to “disappear” messages or set remote deletion deadlines. That enables users to have much more control over how long people can access what you’re sending them. Given that Russian law enforcement officials are reportedly (via Insider) stopping people in the street and demanding to read their text messages, this could be vital to protect individuals from reprisals. The last couple days have exemplified that uncertainty. On Thursday, news emerged that talks in Turkey between the Russia and Ukraine yielded no positive result. But on Friday, Reuters reported that Russian President Vladimir Putin said there had been some “positive shifts” in talks between the two sides.
from cn
