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科学家发现赋予猫橙色皮毛的基因

2024-12-02 17:37 by 引路人

长期以来,科学家一直对玳瑁猫和印花布猫着迷——它们是黑猫和橘猫的后代。这种杂交的多色猫几乎都是雌性,表明使毛色变为橙色或黑色的基因变异位于 X 染色体上。包括人类在内的大多数哺乳动物中,红毛是由一种细胞表面蛋白 Mc1r 的突变引起,但是编码 Mc1r 的基因似乎并不能解释猫的橙色皮毛是从哪里来的。它不在猫或任何其他物种的 X 染色体上,而且大多数橙色的猫没有 Mc1r 突变。研究团队从动物诊所的猫身上收集了 4 个橙色和 4 个非橙色胎儿的皮肤样本。为了确定单个皮肤细胞如何表达基因,研究人员测量了每个黑素细胞产生的RNA的数量,并确定了它编码的基因。他们发现,橙色猫的黑色素细胞从一种名为 Arhgap36 的基因中产生的 RNA 是普通猫的 13 倍。该基因位于 X 染色体上。但当研究人员在橙色猫身上观察 Arhgap36 的基因序列时,没有发现编码 Arhgap36 蛋白的 DNA 有任何突变。相反他们发现橙色猫缺少附近的一段 DNA,这段 DNA 不会影响蛋白质的氨基酸成分,但可能参与调节细胞产生的氨基酸量。研究团队扫描了 188 只猫的基因组数据库,发现每只橘猫、印花布猫和玳瑁猫都有完全相同的突变。他们在 bioRxiv 上报告了这一发现。

https://www.biorxiv.org/content/10.1101/2024.11.21.624608v1.full.pdf
https://news.sciencenet.cn/htmlnews/2024/12/535040.shtm

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科学家发现赋予猫橙色皮毛的基因

2024-12-02 17:37 by 引路人

长期以来,科学家一直对玳瑁猫和印花布猫着迷——它们是黑猫和橘猫的后代。这种杂交的多色猫几乎都是雌性,表明使毛色变为橙色或黑色的基因变异位于 X 染色体上。包括人类在内的大多数哺乳动物中,红毛是由一种细胞表面蛋白 Mc1r 的突变引起,但是编码 Mc1r 的基因似乎并不能解释猫的橙色皮毛是从哪里来的。它不在猫或任何其他物种的 X 染色体上,而且大多数橙色的猫没有 Mc1r 突变。研究团队从动物诊所的猫身上收集了 4 个橙色和 4 个非橙色胎儿的皮肤样本。为了确定单个皮肤细胞如何表达基因,研究人员测量了每个黑素细胞产生的RNA的数量,并确定了它编码的基因。他们发现,橙色猫的黑色素细胞从一种名为 Arhgap36 的基因中产生的 RNA 是普通猫的 13 倍。该基因位于 X 染色体上。但当研究人员在橙色猫身上观察 Arhgap36 的基因序列时,没有发现编码 Arhgap36 蛋白的 DNA 有任何突变。相反他们发现橙色猫缺少附近的一段 DNA,这段 DNA 不会影响蛋白质的氨基酸成分,但可能参与调节细胞产生的氨基酸量。研究团队扫描了 188 只猫的基因组数据库,发现每只橘猫、印花布猫和玳瑁猫都有完全相同的突变。他们在 bioRxiv 上报告了这一发现。

https://www.biorxiv.org/content/10.1101/2024.11.21.624608v1.full.pdf
https://news.sciencenet.cn/htmlnews/2024/12/535040.shtm

#生物技术

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Founder Pavel Durov says tech is meant to set you free The fake Zelenskiy account reached 20,000 followers on Telegram before it was shut down, a remedial action that experts say is all too rare. Given the pro-privacy stance of the platform, it’s taken as a given that it’ll be used for a number of reasons, not all of them good. And Telegram has been attached to a fair few scandals related to terrorism, sexual exploitation and crime. Back in 2015, Vox described Telegram as “ISIS’ app of choice,” saying that the platform’s real use is the ability to use channels to distribute material to large groups at once. Telegram has acted to remove public channels affiliated with terrorism, but Pavel Durov reiterated that he had no business snooping on private conversations. The account, "War on Fakes," was created on February 24, the same day Russian President Vladimir Putin announced a "special military operation" and troops began invading Ukraine. The page is rife with disinformation, according to The Atlantic Council's Digital Forensic Research Lab, which studies digital extremism and published a report examining the channel. "For Telegram, accountability has always been a problem, which is why it was so popular even before the full-scale war with far-right extremists and terrorists from all over the world," she told AFP from her safe house outside the Ukrainian capital.
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