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πŸ’‘ ΠžΡ†Π΅Π½ΠΈΠ»ΠΈ возмоТности использования Π³ΠΈΠ±Ρ€ΠΈΠ΄Π½Ρ‹Ρ… Π½Π°Π½ΠΎΠ²Π΅Π·ΠΈΠΊΡƒΠ» Π² качСствС систСмы доставки РНК 🎯

Π˜Π½Ρ‚Π΅Ρ€Π΅Ρ ΠΊ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Π°ΠΌ Π½Π° основС РНК растСт, Π½ΠΎ ΠΈΡ… использованиС ΠΎΠ³Ρ€Π°Π½ΠΈΡ‡Π΅Π½ΠΎ отсутствиСм Π΄Π°Π½Π½Ρ‹Ρ… ΠΏΠΎ бСзопасности ΠΈ эффСктивности систСм доставок πŸ“¦

πŸ«±πŸ»β€πŸ«²πŸΌ Π’ Π½Π΅Π΄Π°Π²Π½Π΅ΠΌ исслСдовании, Π²Π΄ΠΎΡ…Π½ΠΎΠ²Π»Π΅Π½Π½ΠΎΠΌ ΠΊΠΎΠ»Π»Π΅Π³Π°ΠΌΠΈ ΠΈΠ· БСчСновского унивСрситСта, УнивСрситСта Бириус, ΠœΠ“Π£ ΠΈΠΌ. М.Π’. Ломоносова, Научного Ρ†Π΅Π½Ρ‚Ρ€Π° исслСдований ΠΈ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ иммунобиологичСских ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΎΠ² ΠΈΠΌΠ΅Π½ΠΈ М.П. Π§ΡƒΠΌΠ°ΠΊΠΎΠ²Π° ΠΈ Π˜Π‘Π₯ РАН, ΠΌΡ‹ ΠΈΠ·ΡƒΡ‡ΠΈΠ»ΠΈ Π²Π½Π΅ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Π΅ Π½Π°Π½ΠΎΠ²Π΅Π·ΠΈΠΊΡƒΠ»Ρ‹ 🦠

Π‘Ρ‹Π»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, Ρ‡Ρ‚ΠΎ прСдлоТСнная Π² ΡΡ‚Π°Ρ‚ΡŒΠ΅ модификация наночастиц ΠΏΡ€ΠΈΠ²ΠΎΠ΄ΠΈΡ‚ ΠΊ Π±ΠΎΠ»Π΅Π΅ Ρ‡Π΅ΠΌ 10-ΠΊΡ€Π°Ρ‚Π½ΠΎΠΌΡƒ ΡƒΡΠΈΠ»Π΅Π½ΠΈΡŽ ΠΈΠ½Ρ‚Π΅Ρ€Π½Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ наночастиц in vitro ΠΈ Π±ΠΎΠ»Π΅Π΅, Ρ‡Π΅ΠΌ Π² 2 Ρ€Π°Π·Π° in vivo. Доставка РНК с использованиСм Π³ΠΈΠ±Ρ€ΠΈΠ΄ΠΎΠ² продСмонстрировала ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ >85% Π² ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Ρ… линиях Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΠΌΡ‹ΡˆΠΈ 🐁

πŸ“ƒ ΠŸΠΎΠ΄Ρ€ΠΎΠ±Π½Π΅Π΅ ΠΏΠΎΡ‡ΠΈΡ‚Π°Ρ‚ΡŒ ΠΌΠΎΠΆΠ½ΠΎ: https://doi.org/10.1016/j.ymthe.2024.11.004
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πŸ’‘ ΠžΡ†Π΅Π½ΠΈΠ»ΠΈ возмоТности использования Π³ΠΈΠ±Ρ€ΠΈΠ΄Π½Ρ‹Ρ… Π½Π°Π½ΠΎΠ²Π΅Π·ΠΈΠΊΡƒΠ» Π² качСствС систСмы доставки РНК 🎯

Π˜Π½Ρ‚Π΅Ρ€Π΅Ρ ΠΊ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Π°ΠΌ Π½Π° основС РНК растСт, Π½ΠΎ ΠΈΡ… использованиС ΠΎΠ³Ρ€Π°Π½ΠΈΡ‡Π΅Π½ΠΎ отсутствиСм Π΄Π°Π½Π½Ρ‹Ρ… ΠΏΠΎ бСзопасности ΠΈ эффСктивности систСм доставок πŸ“¦

πŸ«±πŸ»β€πŸ«²πŸΌ Π’ Π½Π΅Π΄Π°Π²Π½Π΅ΠΌ исслСдовании, Π²Π΄ΠΎΡ…Π½ΠΎΠ²Π»Π΅Π½Π½ΠΎΠΌ ΠΊΠΎΠ»Π»Π΅Π³Π°ΠΌΠΈ ΠΈΠ· БСчСновского унивСрситСта, УнивСрситСта Бириус, ΠœΠ“Π£ ΠΈΠΌ. М.Π’. Ломоносова, Научного Ρ†Π΅Π½Ρ‚Ρ€Π° исслСдований ΠΈ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ иммунобиологичСских ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΎΠ² ΠΈΠΌΠ΅Π½ΠΈ М.П. Π§ΡƒΠΌΠ°ΠΊΠΎΠ²Π° ΠΈ Π˜Π‘Π₯ РАН, ΠΌΡ‹ ΠΈΠ·ΡƒΡ‡ΠΈΠ»ΠΈ Π²Π½Π΅ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Π΅ Π½Π°Π½ΠΎΠ²Π΅Π·ΠΈΠΊΡƒΠ»Ρ‹ 🦠

Π‘Ρ‹Π»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, Ρ‡Ρ‚ΠΎ прСдлоТСнная Π² ΡΡ‚Π°Ρ‚ΡŒΠ΅ модификация наночастиц ΠΏΡ€ΠΈΠ²ΠΎΠ΄ΠΈΡ‚ ΠΊ Π±ΠΎΠ»Π΅Π΅ Ρ‡Π΅ΠΌ 10-ΠΊΡ€Π°Ρ‚Π½ΠΎΠΌΡƒ ΡƒΡΠΈΠ»Π΅Π½ΠΈΡŽ ΠΈΠ½Ρ‚Π΅Ρ€Π½Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ наночастиц in vitro ΠΈ Π±ΠΎΠ»Π΅Π΅, Ρ‡Π΅ΠΌ Π² 2 Ρ€Π°Π·Π° in vivo. Доставка РНК с использованиСм Π³ΠΈΠ±Ρ€ΠΈΠ΄ΠΎΠ² продСмонстрировала ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ >85% Π² ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Ρ… линиях Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΠΌΡ‹ΡˆΠΈ 🐁

πŸ“ƒ ΠŸΠΎΠ΄Ρ€ΠΎΠ±Π½Π΅Π΅ ΠΏΠΎΡ‡ΠΈΡ‚Π°Ρ‚ΡŒ ΠΌΠΎΠΆΠ½ΠΎ: https://doi.org/10.1016/j.ymthe.2024.11.004

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In this regard, Sebi collaborated with the Telecom Regulatory Authority of India (TRAI) to reduce the vulnerability of the securities market to manipulation through misuse of mass communication medium like bulk SMS. For tech stocks, β€œthe main thing is yields,” Essaye said. The company maintains that it cannot act against individual or group chats, which are β€œprivate amongst their participants,” but it will respond to requests in relation to sticker sets, channels and bots which are publicly available. During the invasion of Ukraine, Pavel Durov has wrestled with this issue a lot more prominently than he has before. Channels like Donbass Insider and Bellum Acta, as reported by Foreign Policy, started pumping out pro-Russian propaganda as the invasion began. So much so that the Ukrainian National Security and Defense Council issued a statement labeling which accounts are Russian-backed. Ukrainian officials, in potential violation of the Geneva Convention, have shared imagery of dead and captured Russian soldiers on the platform. The War on Fakes channel has repeatedly attempted to push conspiracies that footage from Ukraine is somehow being falsified. One post on the channel from February 24 claimed without evidence that a widely viewed photo of a Ukrainian woman injured in an airstrike in the city of Chuhuiv was doctored and that the woman was seen in a different photo days later without injuries. The post, which has over 600,000 views, also baselessly claimed that the woman's blood was actually makeup or grape juice. As a result, the pandemic saw many newcomers to Telegram, including prominent anti-vaccine activists who used the app's hands-off approach to share false information on shots, a study from the Institute for Strategic Dialogue shows.
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