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Люблю истории, в которых белки меняют профессию. Давеча был описан еще один такой случай. Фермент биосинтеза пуринов de novo, IMPDH2, еще и ухитряется "подрабатывать" в клеточном ядре, регулируя репарацию ДНК! Связываясь с хроматином, он регулирует активность поли(АДФ)рибозополимеразы 1 (PARP1), контролируя уровень НАД+ — субстрата для PARP1. Без IMPDH2 в ядре начинают накапливаться мутации. В общем, личная эффективность IMPDH2 зашкаливает.
Люблю истории, в которых белки меняют профессию. Давеча был описан еще один такой случай. Фермент биосинтеза пуринов de novo, IMPDH2, еще и ухитряется "подрабатывать" в клеточном ядре, регулируя репарацию ДНК! Связываясь с хроматином, он регулирует активность поли(АДФ)рибозополимеразы 1 (PARP1), контролируя уровень НАД+ — субстрата для PARP1. Без IMPDH2 в ядре начинают накапливаться мутации. В общем, личная эффективность IMPDH2 зашкаливает.
Stocks closed in the red Friday as investors weighed upbeat remarks from Russian President Vladimir Putin about diplomatic discussions with Ukraine against a weaker-than-expected print on U.S. consumer sentiment. And while money initially moved into stocks in the morning, capital moved out of safe-haven assets. The price of the 10-year Treasury note fell Friday, sending its yield up to 2% from a March closing low of 1.73%. The War on Fakes channel has repeatedly attempted to push conspiracies that footage from Ukraine is somehow being falsified. One post on the channel from February 24 claimed without evidence that a widely viewed photo of a Ukrainian woman injured in an airstrike in the city of Chuhuiv was doctored and that the woman was seen in a different photo days later without injuries. The post, which has over 600,000 views, also baselessly claimed that the woman's blood was actually makeup or grape juice. To that end, when files are actively downloading, a new icon now appears in the Search bar that users can tap to view and manage downloads, pause and resume all downloads or just individual items, and select one to increase its priority or view it in a chat. There was another possible development: Reuters also reported that Ukraine said that Belarus could soon join the invasion of Ukraine. However, the AFP, citing a Pentagon official, said the U.S. hasn’t yet seen evidence that Belarusian troops are in Ukraine.
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