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Древовидные молекулы доставят ДНК-вакцины в клетки
Ученые предложили простой и дешевый способ синтеза дендримеров — древовидных органических соединений, — способных связывать ДНК. Авторы присоединили к чашеобразной молекуле короткие расходящиеся во все стороны «ветви», благодаря чему получили структуру, которая может использоваться для доставки ДНК-вакцин и лекарств. Эксперименты также показали, что новый дендример нетоксичен, в отличие от большинства существующих аналогов. Результаты исследования, поддержанного грантом Российского научного фонда (РНФ), опубликованы в журнале Pharmaceutics.
Древовидные молекулы доставят ДНК-вакцины в клетки
Ученые предложили простой и дешевый способ синтеза дендримеров — древовидных органических соединений, — способных связывать ДНК. Авторы присоединили к чашеобразной молекуле короткие расходящиеся во все стороны «ветви», благодаря чему получили структуру, которая может использоваться для доставки ДНК-вакцин и лекарств. Эксперименты также показали, что новый дендример нетоксичен, в отличие от большинства существующих аналогов. Результаты исследования, поддержанного грантом Российского научного фонда (РНФ), опубликованы в журнале Pharmaceutics.
Telegram does offer end-to-end encrypted communications through Secret Chats, but this is not the default setting. Standard conversations use the MTProto method, enabling server-client encryption but with them stored on the server for ease-of-access. This makes using Telegram across multiple devices simple, but also means that the regular Telegram chats you’re having with folks are not as secure as you may believe. "The inflation fire was already hot and now with war-driven inflation added to the mix, it will grow even hotter, setting off a scramble by the world’s central banks to pull back their stimulus earlier than expected," Chris Rupkey, chief economist at FWDBONDS, wrote in an email. "A spike in inflation rates has preceded economic recessions historically and this time prices have soared to levels that once again pose a threat to growth." At this point, however, Durov had already been working on Telegram with his brother, and further planned a mobile-first social network with an explicit focus on anti-censorship. Later in April, he told TechCrunch that he had left Russia and had “no plans to go back,” saying that the nation was currently “incompatible with internet business at the moment.” He added later that he was looking for a country that matched his libertarian ideals to base his next startup. The next bit isn’t clear, but Durov reportedly claimed that his resignation, dated March 21st, was an April Fools’ prank. TechCrunch implies that it was a matter of principle, but it’s hard to be clear on the wheres, whos and whys. Similarly, on April 17th, the Moscow Times quoted Durov as saying that he quit the company after being pressured to reveal account details about Ukrainians protesting the then-president Viktor Yanukovych. In the United States, Telegram's lower public profile has helped it mostly avoid high level scrutiny from Congress, but it has not gone unnoticed.
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