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πŸ’‘ ΠžΡ†Π΅Π½ΠΈΠ»ΠΈ возмоТности использования Π³ΠΈΠ±Ρ€ΠΈΠ΄Π½Ρ‹Ρ… Π½Π°Π½ΠΎΠ²Π΅Π·ΠΈΠΊΡƒΠ» Π² качСствС систСмы доставки РНК 🎯

Π˜Π½Ρ‚Π΅Ρ€Π΅Ρ ΠΊ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Π°ΠΌ Π½Π° основС РНК растСт, Π½ΠΎ ΠΈΡ… использованиС ΠΎΠ³Ρ€Π°Π½ΠΈΡ‡Π΅Π½ΠΎ отсутствиСм Π΄Π°Π½Π½Ρ‹Ρ… ΠΏΠΎ бСзопасности ΠΈ эффСктивности систСм доставок πŸ“¦

πŸ«±πŸ»β€πŸ«²πŸΌ Π’ Π½Π΅Π΄Π°Π²Π½Π΅ΠΌ исслСдовании, Π²Π΄ΠΎΡ…Π½ΠΎΠ²Π»Π΅Π½Π½ΠΎΠΌ ΠΊΠΎΠ»Π»Π΅Π³Π°ΠΌΠΈ ΠΈΠ· БСчСновского унивСрситСта, УнивСрситСта Бириус, ΠœΠ“Π£ ΠΈΠΌ. М.Π’. Ломоносова, Научного Ρ†Π΅Π½Ρ‚Ρ€Π° исслСдований ΠΈ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ иммунобиологичСских ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΎΠ² ΠΈΠΌΠ΅Π½ΠΈ М.П. Π§ΡƒΠΌΠ°ΠΊΠΎΠ²Π° ΠΈ Π˜Π‘Π₯ РАН, ΠΌΡ‹ ΠΈΠ·ΡƒΡ‡ΠΈΠ»ΠΈ Π²Π½Π΅ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Π΅ Π½Π°Π½ΠΎΠ²Π΅Π·ΠΈΠΊΡƒΠ»Ρ‹ 🦠

Π‘Ρ‹Π»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, Ρ‡Ρ‚ΠΎ прСдлоТСнная Π² ΡΡ‚Π°Ρ‚ΡŒΠ΅ модификация наночастиц ΠΏΡ€ΠΈΠ²ΠΎΠ΄ΠΈΡ‚ ΠΊ Π±ΠΎΠ»Π΅Π΅ Ρ‡Π΅ΠΌ 10-ΠΊΡ€Π°Ρ‚Π½ΠΎΠΌΡƒ ΡƒΡΠΈΠ»Π΅Π½ΠΈΡŽ ΠΈΠ½Ρ‚Π΅Ρ€Π½Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ наночастиц in vitro ΠΈ Π±ΠΎΠ»Π΅Π΅, Ρ‡Π΅ΠΌ Π² 2 Ρ€Π°Π·Π° in vivo. Доставка РНК с использованиСм Π³ΠΈΠ±Ρ€ΠΈΠ΄ΠΎΠ² продСмонстрировала ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ >85% Π² ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Ρ… линиях Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΠΌΡ‹ΡˆΠΈ 🐁

πŸ“ƒ ΠŸΠΎΠ΄Ρ€ΠΎΠ±Π½Π΅Π΅ ΠΏΠΎΡ‡ΠΈΡ‚Π°Ρ‚ΡŒ ΠΌΠΎΠΆΠ½ΠΎ: https://doi.org/10.1016/j.ymthe.2024.11.004
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πŸ’‘ ΠžΡ†Π΅Π½ΠΈΠ»ΠΈ возмоТности использования Π³ΠΈΠ±Ρ€ΠΈΠ΄Π½Ρ‹Ρ… Π½Π°Π½ΠΎΠ²Π΅Π·ΠΈΠΊΡƒΠ» Π² качСствС систСмы доставки РНК 🎯

Π˜Π½Ρ‚Π΅Ρ€Π΅Ρ ΠΊ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Π°ΠΌ Π½Π° основС РНК растСт, Π½ΠΎ ΠΈΡ… использованиС ΠΎΠ³Ρ€Π°Π½ΠΈΡ‡Π΅Π½ΠΎ отсутствиСм Π΄Π°Π½Π½Ρ‹Ρ… ΠΏΠΎ бСзопасности ΠΈ эффСктивности систСм доставок πŸ“¦

πŸ«±πŸ»β€πŸ«²πŸΌ Π’ Π½Π΅Π΄Π°Π²Π½Π΅ΠΌ исслСдовании, Π²Π΄ΠΎΡ…Π½ΠΎΠ²Π»Π΅Π½Π½ΠΎΠΌ ΠΊΠΎΠ»Π»Π΅Π³Π°ΠΌΠΈ ΠΈΠ· БСчСновского унивСрситСта, УнивСрситСта Бириус, ΠœΠ“Π£ ΠΈΠΌ. М.Π’. Ломоносова, Научного Ρ†Π΅Π½Ρ‚Ρ€Π° исслСдований ΠΈ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ иммунобиологичСских ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΎΠ² ΠΈΠΌΠ΅Π½ΠΈ М.П. Π§ΡƒΠΌΠ°ΠΊΠΎΠ²Π° ΠΈ Π˜Π‘Π₯ РАН, ΠΌΡ‹ ΠΈΠ·ΡƒΡ‡ΠΈΠ»ΠΈ Π²Π½Π΅ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Π΅ Π½Π°Π½ΠΎΠ²Π΅Π·ΠΈΠΊΡƒΠ»Ρ‹ 🦠

Π‘Ρ‹Π»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, Ρ‡Ρ‚ΠΎ прСдлоТСнная Π² ΡΡ‚Π°Ρ‚ΡŒΠ΅ модификация наночастиц ΠΏΡ€ΠΈΠ²ΠΎΠ΄ΠΈΡ‚ ΠΊ Π±ΠΎΠ»Π΅Π΅ Ρ‡Π΅ΠΌ 10-ΠΊΡ€Π°Ρ‚Π½ΠΎΠΌΡƒ ΡƒΡΠΈΠ»Π΅Π½ΠΈΡŽ ΠΈΠ½Ρ‚Π΅Ρ€Π½Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ наночастиц in vitro ΠΈ Π±ΠΎΠ»Π΅Π΅, Ρ‡Π΅ΠΌ Π² 2 Ρ€Π°Π·Π° in vivo. Доставка РНК с использованиСм Π³ΠΈΠ±Ρ€ΠΈΠ΄ΠΎΠ² продСмонстрировала ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ >85% Π² ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Ρ… линиях Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΠΌΡ‹ΡˆΠΈ 🐁

πŸ“ƒ ΠŸΠΎΠ΄Ρ€ΠΎΠ±Π½Π΅Π΅ ΠΏΠΎΡ‡ΠΈΡ‚Π°Ρ‚ΡŒ ΠΌΠΎΠΆΠ½ΠΎ: https://doi.org/10.1016/j.ymthe.2024.11.004

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The perpetrators use various names to carry out the investment scams. They may also impersonate or clone licensed capital market intermediaries by using the names, logos, credentials, websites and other details of the legitimate entities to promote the illegal schemes. That hurt tech stocks. For the past few weeks, the 10-year yield has traded between 1.72% and 2%, as traders moved into the bond for safety when Russia headlines were uglyβ€”and out of it when headlines improved. Now, the yield is touching its pandemic-era high. If the yield breaks above that level, that could signal that it’s on a sustainable path higher. Higher long-dated bond yields make future profits less valuableβ€”and many tech companies are valued on the basis of profits forecast for many years in the future. The company maintains that it cannot act against individual or group chats, which are β€œprivate amongst their participants,” but it will respond to requests in relation to sticker sets, channels and bots which are publicly available. During the invasion of Ukraine, Pavel Durov has wrestled with this issue a lot more prominently than he has before. Channels like Donbass Insider and Bellum Acta, as reported by Foreign Policy, started pumping out pro-Russian propaganda as the invasion began. So much so that the Ukrainian National Security and Defense Council issued a statement labeling which accounts are Russian-backed. Ukrainian officials, in potential violation of the Geneva Convention, have shared imagery of dead and captured Russian soldiers on the platform. For tech stocks, β€œthe main thing is yields,” Essaye said. Asked about its stance on disinformation, Telegram spokesperson Remi Vaughn told AFP: "As noted by our CEO, the sheer volume of information being shared on channels makes it extremely difficult to verify, so it's important that users double-check what they read."
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