📝این مقاله SPLICE-q را به عنوان یک نرمافزار مبتنی بر Python برای تحلیل کارایی برش ژنهایی بهصورت گسترده با استفاده از دادههای توالییابی RNA (RNA-seq) معرفی میکند. Splicing، یک مرحلهی حیاتی در بیان ژن است که شامل حذف اینترونها از پیش RNA (pre-mRNA) برای تولید RNA بالغ میشود. این مطالعه به اهمیت اندازهگیری کارایی برش برای درک دینامیک آن و پیامدهای آن، بهویژه در زمینه بیماریهایی مانند سرطان، میپردازد.
📝این مقاله SPLICE-q را به عنوان یک نرمافزار مبتنی بر Python برای تحلیل کارایی برش ژنهایی بهصورت گسترده با استفاده از دادههای توالییابی RNA (RNA-seq) معرفی میکند. Splicing، یک مرحلهی حیاتی در بیان ژن است که شامل حذف اینترونها از پیش RNA (pre-mRNA) برای تولید RNA بالغ میشود. این مطالعه به اهمیت اندازهگیری کارایی برش برای درک دینامیک آن و پیامدهای آن، بهویژه در زمینه بیماریهایی مانند سرطان، میپردازد.
In 2018, Russia banned Telegram although it reversed the prohibition two years later. The next bit isn’t clear, but Durov reportedly claimed that his resignation, dated March 21st, was an April Fools’ prank. TechCrunch implies that it was a matter of principle, but it’s hard to be clear on the wheres, whos and whys. Similarly, on April 17th, the Moscow Times quoted Durov as saying that he quit the company after being pressured to reveal account details about Ukrainians protesting the then-president Viktor Yanukovych. Overall, extreme levels of fear in the market seems to have morphed into something more resembling concern. For example, the Cboe Volatility Index fell from its 2022 peak of 36, which it hit Monday, to around 30 on Friday, a sign of easing tensions. Meanwhile, while the price of WTI crude oil slipped from Sunday’s multiyear high $130 of barrel to $109 a pop. Markets have been expecting heavy restrictions on Russian oil, some of which the U.S. has already imposed, and that would reduce the global supply and bring about even more burdensome inflation. Pavel Durov, a billionaire who embraces an all-black wardrobe and is often compared to the character Neo from "the Matrix," funds Telegram through his personal wealth and debt financing. And despite being one of the world's most popular tech companies, Telegram reportedly has only about 30 employees who defer to Durov for most major decisions about the platform. Again, in contrast to Facebook, Google and Twitter, Telegram's founder Pavel Durov runs his company in relative secrecy from Dubai.
from jp