Люблю истории, в которых белки меняют профессию. Давеча был описан еще один такой случай. Фермент биосинтеза пуринов de novo, IMPDH2, еще и ухитряется "подрабатывать" в клеточном ядре, регулируя репарацию ДНК! Связываясь с хроматином, он регулирует активность поли(АДФ)рибозополимеразы 1 (PARP1), контролируя уровень НАД+ — субстрата для PARP1. Без IMPDH2 в ядре начинают накапливаться мутации. В общем, личная эффективность IMPDH2 зашкаливает.
Люблю истории, в которых белки меняют профессию. Давеча был описан еще один такой случай. Фермент биосинтеза пуринов de novo, IMPDH2, еще и ухитряется "подрабатывать" в клеточном ядре, регулируя репарацию ДНК! Связываясь с хроматином, он регулирует активность поли(АДФ)рибозополимеразы 1 (PARP1), контролируя уровень НАД+ — субстрата для PARP1. Без IMPDH2 в ядре начинают накапливаться мутации. В общем, личная эффективность IMPDH2 зашкаливает.
The gold standard of encryption, known as end-to-end encryption, where only the sender and person who receives the message are able to see it, is available on Telegram only when the Secret Chat function is enabled. Voice and video calls are also completely encrypted. Apparently upbeat developments in Russia's discussions with Ukraine helped at least temporarily send investors back into risk assets. Russian President Vladimir Putin said during a meeting with his Belarusian counterpart Alexander Lukashenko that there were "certain positive developments" occurring in the talks with Ukraine, according to a transcript of their meeting. Putin added that discussions were happening "almost on a daily basis." Pavel Durov, a billionaire who embraces an all-black wardrobe and is often compared to the character Neo from "the Matrix," funds Telegram through his personal wealth and debt financing. And despite being one of the world's most popular tech companies, Telegram reportedly has only about 30 employees who defer to Durov for most major decisions about the platform. Pavel Durov, Telegram's CEO, is known as "the Russian Mark Zuckerberg," for co-founding VKontakte, which is Russian for "in touch," a Facebook imitator that became the country's most popular social networking site. False news often spreads via public groups, or chats, with potentially fatal effects.
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