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🔴 Oneway for Don't eat me signal is an interaction between CD47 and SIRPalpha. SIRP family has three different subtypes include Alpha, Beta, and Gamma.
🟠 In cancer cells interaction between SIRPalpha and CD inhibits macrophages to select cancer cells and macrophage phagocytosis and also this mechanism help cancer cells to evade the immunity.
🟡 Many studies shown that overexpression and higher levels of CD47 in tumor cells surface than non-malignant cells.
🟢 By exploiting the "Don't eat me" signal, cancer cells utilize CD47's overexpression to evade immune cell surveillance and clearance, making CD47 a potential target for novel anti-tumor therapies.
🔴 Oneway for Don't eat me signal is an interaction between CD47 and SIRPalpha. SIRP family has three different subtypes include Alpha, Beta, and Gamma.
🟠 In cancer cells interaction between SIRPalpha and CD inhibits macrophages to select cancer cells and macrophage phagocytosis and also this mechanism help cancer cells to evade the immunity.
🟡 Many studies shown that overexpression and higher levels of CD47 in tumor cells surface than non-malignant cells.
🟢 By exploiting the "Don't eat me" signal, cancer cells utilize CD47's overexpression to evade immune cell surveillance and clearance, making CD47 a potential target for novel anti-tumor therapies.
Messages are not fully encrypted by default. That means the company could, in theory, access the content of the messages, or be forced to hand over the data at the request of a government. Emerson Brooking, a disinformation expert at the Atlantic Council's Digital Forensic Research Lab, said: "Back in the Wild West period of content moderation, like 2014 or 2015, maybe they could have gotten away with it, but it stands in marked contrast with how other companies run themselves today." There was another possible development: Reuters also reported that Ukraine said that Belarus could soon join the invasion of Ukraine. However, the AFP, citing a Pentagon official, said the U.S. hasn’t yet seen evidence that Belarusian troops are in Ukraine. The original Telegram channel has expanded into a web of accounts for different locations, including specific pages made for individual Russian cities. There's also an English-language website, which states it is owned by the people who run the Telegram channels. Such instructions could actually endanger people — citizens receive air strike warnings via smartphone alerts.
from ms