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Большинство современных суррогатных КТ в кардиологии, которые продемонстрировали свою связь с клиническими исходами, были изучены в рамках крупных проспективных эпидемиологических и рандомизированных исследований. Влияние уровня гликемии, уровня АД и высоких показателей липидов крови на сердечно-сосудистые события были выявлены в крупных международных исследованиях: UKPDS (United Kingdom Prospective Diabetes Study), DECODE (Diabetes Epidemiology: Collaborative analysis of Diagnostic criteria in Europe), Фремингемское исследование, Мюнстерское исследование, исследование MRFIT (Multiple Risk Factor Intervention Trial) и др.
Дополнительную информацию вы можете увидеть в прикрепленной таблице.
В последующем посте приведём пример, когда результат по важным клиническим исходам достигался на фоне отстутсивия изменений по суррогатным показателям.
Большинство современных суррогатных КТ в кардиологии, которые продемонстрировали свою связь с клиническими исходами, были изучены в рамках крупных проспективных эпидемиологических и рандомизированных исследований. Влияние уровня гликемии, уровня АД и высоких показателей липидов крови на сердечно-сосудистые события были выявлены в крупных международных исследованиях: UKPDS (United Kingdom Prospective Diabetes Study), DECODE (Diabetes Epidemiology: Collaborative analysis of Diagnostic criteria in Europe), Фремингемское исследование, Мюнстерское исследование, исследование MRFIT (Multiple Risk Factor Intervention Trial) и др.
Дополнительную информацию вы можете увидеть в прикрепленной таблице.
В последующем посте приведём пример, когда результат по важным клиническим исходам достигался на фоне отстутсивия изменений по суррогатным показателям.
"There are a lot of things that Telegram could have been doing this whole time. And they know exactly what they are and they've chosen not to do them. That's why I don't trust them," she said. At this point, however, Durov had already been working on Telegram with his brother, and further planned a mobile-first social network with an explicit focus on anti-censorship. Later in April, he told TechCrunch that he had left Russia and had “no plans to go back,” saying that the nation was currently “incompatible with internet business at the moment.” He added later that he was looking for a country that matched his libertarian ideals to base his next startup. But Telegram says people want to keep their chat history when they get a new phone, and they like having a data backup that will sync their chats across multiple devices. And that is why they let people choose whether they want their messages to be encrypted or not. When not turned on, though, chats are stored on Telegram's services, which are scattered throughout the world. But it has "disclosed 0 bytes of user data to third parties, including governments," Telegram states on its website. Unlike Silicon Valley giants such as Facebook and Twitter, which run very public anti-disinformation programs, Brooking said: "Telegram is famously lax or absent in its content moderation policy." "For Telegram, accountability has always been a problem, which is why it was so popular even before the full-scale war with far-right extremists and terrorists from all over the world," she told AFP from her safe house outside the Ukrainian capital.
from nl
