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πŸ’‘ ΠžΡ†Π΅Π½ΠΈΠ»ΠΈ возмоТности использования Π³ΠΈΠ±Ρ€ΠΈΠ΄Π½Ρ‹Ρ… Π½Π°Π½ΠΎΠ²Π΅Π·ΠΈΠΊΡƒΠ» Π² качСствС систСмы доставки РНК 🎯

Π˜Π½Ρ‚Π΅Ρ€Π΅Ρ ΠΊ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Π°ΠΌ Π½Π° основС РНК растСт, Π½ΠΎ ΠΈΡ… использованиС ΠΎΠ³Ρ€Π°Π½ΠΈΡ‡Π΅Π½ΠΎ отсутствиСм Π΄Π°Π½Π½Ρ‹Ρ… ΠΏΠΎ бСзопасности ΠΈ эффСктивности систСм доставок πŸ“¦

πŸ«±πŸ»β€πŸ«²πŸΌ Π’ Π½Π΅Π΄Π°Π²Π½Π΅ΠΌ исслСдовании, Π²Π΄ΠΎΡ…Π½ΠΎΠ²Π»Π΅Π½Π½ΠΎΠΌ ΠΊΠΎΠ»Π»Π΅Π³Π°ΠΌΠΈ ΠΈΠ· БСчСновского унивСрситСта, УнивСрситСта Бириус, ΠœΠ“Π£ ΠΈΠΌ. М.Π’. Ломоносова, Научного Ρ†Π΅Π½Ρ‚Ρ€Π° исслСдований ΠΈ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ иммунобиологичСских ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΎΠ² ΠΈΠΌΠ΅Π½ΠΈ М.П. Π§ΡƒΠΌΠ°ΠΊΠΎΠ²Π° ΠΈ Π˜Π‘Π₯ РАН, ΠΌΡ‹ ΠΈΠ·ΡƒΡ‡ΠΈΠ»ΠΈ Π²Π½Π΅ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Π΅ Π½Π°Π½ΠΎΠ²Π΅Π·ΠΈΠΊΡƒΠ»Ρ‹ 🦠

Π‘Ρ‹Π»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, Ρ‡Ρ‚ΠΎ прСдлоТСнная Π² ΡΡ‚Π°Ρ‚ΡŒΠ΅ модификация наночастиц ΠΏΡ€ΠΈΠ²ΠΎΠ΄ΠΈΡ‚ ΠΊ Π±ΠΎΠ»Π΅Π΅ Ρ‡Π΅ΠΌ 10-ΠΊΡ€Π°Ρ‚Π½ΠΎΠΌΡƒ ΡƒΡΠΈΠ»Π΅Π½ΠΈΡŽ ΠΈΠ½Ρ‚Π΅Ρ€Π½Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ наночастиц in vitro ΠΈ Π±ΠΎΠ»Π΅Π΅, Ρ‡Π΅ΠΌ Π² 2 Ρ€Π°Π·Π° in vivo. Доставка РНК с использованиСм Π³ΠΈΠ±Ρ€ΠΈΠ΄ΠΎΠ² продСмонстрировала ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ >85% Π² ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Ρ… линиях Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΠΌΡ‹ΡˆΠΈ 🐁

πŸ“ƒ ΠŸΠΎΠ΄Ρ€ΠΎΠ±Π½Π΅Π΅ ΠΏΠΎΡ‡ΠΈΡ‚Π°Ρ‚ΡŒ ΠΌΠΎΠΆΠ½ΠΎ: https://doi.org/10.1016/j.ymthe.2024.11.004
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πŸ’‘ ΠžΡ†Π΅Π½ΠΈΠ»ΠΈ возмоТности использования Π³ΠΈΠ±Ρ€ΠΈΠ΄Π½Ρ‹Ρ… Π½Π°Π½ΠΎΠ²Π΅Π·ΠΈΠΊΡƒΠ» Π² качСствС систСмы доставки РНК 🎯

Π˜Π½Ρ‚Π΅Ρ€Π΅Ρ ΠΊ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Π°ΠΌ Π½Π° основС РНК растСт, Π½ΠΎ ΠΈΡ… использованиС ΠΎΠ³Ρ€Π°Π½ΠΈΡ‡Π΅Π½ΠΎ отсутствиСм Π΄Π°Π½Π½Ρ‹Ρ… ΠΏΠΎ бСзопасности ΠΈ эффСктивности систСм доставок πŸ“¦

πŸ«±πŸ»β€πŸ«²πŸΌ Π’ Π½Π΅Π΄Π°Π²Π½Π΅ΠΌ исслСдовании, Π²Π΄ΠΎΡ…Π½ΠΎΠ²Π»Π΅Π½Π½ΠΎΠΌ ΠΊΠΎΠ»Π»Π΅Π³Π°ΠΌΠΈ ΠΈΠ· БСчСновского унивСрситСта, УнивСрситСта Бириус, ΠœΠ“Π£ ΠΈΠΌ. М.Π’. Ломоносова, Научного Ρ†Π΅Π½Ρ‚Ρ€Π° исслСдований ΠΈ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ иммунобиологичСских ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΎΠ² ΠΈΠΌΠ΅Π½ΠΈ М.П. Π§ΡƒΠΌΠ°ΠΊΠΎΠ²Π° ΠΈ Π˜Π‘Π₯ РАН, ΠΌΡ‹ ΠΈΠ·ΡƒΡ‡ΠΈΠ»ΠΈ Π²Π½Π΅ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Π΅ Π½Π°Π½ΠΎΠ²Π΅Π·ΠΈΠΊΡƒΠ»Ρ‹ 🦠

Π‘Ρ‹Π»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, Ρ‡Ρ‚ΠΎ прСдлоТСнная Π² ΡΡ‚Π°Ρ‚ΡŒΠ΅ модификация наночастиц ΠΏΡ€ΠΈΠ²ΠΎΠ΄ΠΈΡ‚ ΠΊ Π±ΠΎΠ»Π΅Π΅ Ρ‡Π΅ΠΌ 10-ΠΊΡ€Π°Ρ‚Π½ΠΎΠΌΡƒ ΡƒΡΠΈΠ»Π΅Π½ΠΈΡŽ ΠΈΠ½Ρ‚Π΅Ρ€Π½Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ наночастиц in vitro ΠΈ Π±ΠΎΠ»Π΅Π΅, Ρ‡Π΅ΠΌ Π² 2 Ρ€Π°Π·Π° in vivo. Доставка РНК с использованиСм Π³ΠΈΠ±Ρ€ΠΈΠ΄ΠΎΠ² продСмонстрировала ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ >85% Π² ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Ρ… линиях Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΠΌΡ‹ΡˆΠΈ 🐁

πŸ“ƒ ΠŸΠΎΠ΄Ρ€ΠΎΠ±Π½Π΅Π΅ ΠΏΠΎΡ‡ΠΈΡ‚Π°Ρ‚ΡŒ ΠΌΠΎΠΆΠ½ΠΎ: https://doi.org/10.1016/j.ymthe.2024.11.004

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One thing that Telegram now offers to all users is the ability to β€œdisappear” messages or set remote deletion deadlines. That enables users to have much more control over how long people can access what you’re sending them. Given that Russian law enforcement officials are reportedly (via Insider) stopping people in the street and demanding to read their text messages, this could be vital to protect individuals from reprisals. On December 23rd, 2020, Pavel Durov posted to his channel that the company would need to start generating revenue. In early 2021, he added that any advertising on the platform would not use user data for targeting, and that it would be focused on β€œlarge one-to-many channels.” He pledged that ads would be β€œnon-intrusive” and that most users would simply not notice any change. Ukrainian forces have since put up a strong resistance to the Russian troops amid the war that has left hundreds of Ukrainian civilians, including children, dead, according to the United Nations. Ukrainian and international officials have accused Russia of targeting civilian populations with shelling and bombardments. "He has to start being more proactive and to find a real solution to this situation, not stay in standby without interfering. It's a very irresponsible position from the owner of Telegram," she said. Given the pro-privacy stance of the platform, it’s taken as a given that it’ll be used for a number of reasons, not all of them good. And Telegram has been attached to a fair few scandals related to terrorism, sexual exploitation and crime. Back in 2015, Vox described Telegram as β€œISIS’ app of choice,” saying that the platform’s real use is the ability to use channels to distribute material to large groups at once. Telegram has acted to remove public channels affiliated with terrorism, but Pavel Durov reiterated that he had no business snooping on private conversations.
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