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暴力引发的基因表观遗传能持续数代

2025-02-28 18:21 by 彗星来临

1982 年,叙利亚政府军在老阿萨德的命令下在哈马市屠杀了数万本国居民。40 年后,反叛武装借助大屠杀的记忆推翻了阿萨德家族的统治。这次大屠杀的记忆也印刻了基因里,首次在人类身上提供了压力跨代遗传的证据。我们的基因本身不会因为生活经历而改变,但基因表达会。为了适应压力环境,细胞会在基因上添加化学标记以改变其行为。研究人员跟踪了叙利亚移民家族的三代人,部分家族经历了哈马市暴力袭击事件,部分家庭没有。研究人员从 48 个家庭 138 人身上收集了遗传样本,分析了 DNA 的表观遗传修饰。在哈马幸存者的孙辈中,研究人员发现基因组中有 14 个区域因祖母所经历的暴力事件而发生改变,表明压力引起的表观遗传变化确实能在多代人中间遗传。暂时不清楚表观遗传变化对人生活的影响。此前有研究指出饥荒引发的表观遗传变化会增加后代在成年后肥胖的几率。

Eurekalert:Violence alters human genes for generations, researchers discover

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暴力引发的基因表观遗传能持续数代

2025-02-28 18:21 by 彗星来临

1982 年,叙利亚政府军在老阿萨德的命令下在哈马市屠杀了数万本国居民。40 年后,反叛武装借助大屠杀的记忆推翻了阿萨德家族的统治。这次大屠杀的记忆也印刻了基因里,首次在人类身上提供了压力跨代遗传的证据。我们的基因本身不会因为生活经历而改变,但基因表达会。为了适应压力环境,细胞会在基因上添加化学标记以改变其行为。研究人员跟踪了叙利亚移民家族的三代人,部分家族经历了哈马市暴力袭击事件,部分家庭没有。研究人员从 48 个家庭 138 人身上收集了遗传样本,分析了 DNA 的表观遗传修饰。在哈马幸存者的孙辈中,研究人员发现基因组中有 14 个区域因祖母所经历的暴力事件而发生改变,表明压力引起的表观遗传变化确实能在多代人中间遗传。暂时不清楚表观遗传变化对人生活的影响。此前有研究指出饥荒引发的表观遗传变化会增加后代在成年后肥胖的几率。

Eurekalert:Violence alters human genes for generations, researchers discover

#生物技术

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