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Люблю истории, в которых белки меняют профессию. Давеча был описан еще один такой случай. Фермент биосинтеза пуринов de novo, IMPDH2, еще и ухитряется "подрабатывать" в клеточном ядре, регулируя репарацию ДНК! Связываясь с хроматином, он регулирует активность поли(АДФ)рибозополимеразы 1 (PARP1), контролируя уровень НАД+ — субстрата для PARP1. Без IMPDH2 в ядре начинают накапливаться мутации. В общем, личная эффективность IMPDH2 зашкаливает.



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Люблю истории, в которых белки меняют профессию. Давеча был описан еще один такой случай. Фермент биосинтеза пуринов de novo, IMPDH2, еще и ухитряется "подрабатывать" в клеточном ядре, регулируя репарацию ДНК! Связываясь с хроматином, он регулирует активность поли(АДФ)рибозополимеразы 1 (PARP1), контролируя уровень НАД+ — субстрата для PARP1. Без IMPDH2 в ядре начинают накапливаться мутации. В общем, личная эффективность IMPDH2 зашкаливает.

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