Люблю истории, в которых белки меняют профессию. Давеча был описан еще один такой случай. Фермент биосинтеза пуринов de novo, IMPDH2, еще и ухитряется "подрабатывать" в клеточном ядре, регулируя репарацию ДНК! Связываясь с хроматином, он регулирует активность поли(АДФ)рибозополимеразы 1 (PARP1), контролируя уровень НАД+ — субстрата для PARP1. Без IMPDH2 в ядре начинают накапливаться мутации. В общем, личная эффективность IMPDH2 зашкаливает.
Люблю истории, в которых белки меняют профессию. Давеча был описан еще один такой случай. Фермент биосинтеза пуринов de novo, IMPDH2, еще и ухитряется "подрабатывать" в клеточном ядре, регулируя репарацию ДНК! Связываясь с хроматином, он регулирует активность поли(АДФ)рибозополимеразы 1 (PARP1), контролируя уровень НАД+ — субстрата для PARP1. Без IMPDH2 в ядре начинают накапливаться мутации. В общем, личная эффективность IMPDH2 зашкаливает.
The picture was mixed overseas. Hong Kong’s Hang Seng Index fell 1.6%, under pressure from U.S. regulatory scrutiny on New York-listed Chinese companies. Stocks were more buoyant in Europe, where Frankfurt’s DAX surged 1.4%. The S&P 500 fell 1.3% to 4,204.36, and the Dow Jones Industrial Average was down 0.7% to 32,943.33. The Dow posted a fifth straight weekly loss — its longest losing streak since 2019. The Nasdaq Composite tumbled 2.2% to 12,843.81. Though all three indexes opened in the green, stocks took a turn after a new report showed U.S. consumer sentiment deteriorated more than expected in early March as consumers' inflation expectations soared to the highest since 1981. Since January 2022, the SC has received a total of 47 complaints and enquiries on illegal investment schemes promoted through Telegram. These fraudulent schemes offer non-existent investment opportunities, promising very attractive and risk-free returns within a short span of time. They commonly offer unrealistic returns of as high as 1,000% within 24 hours or even within a few hours. And indeed, volatility has been a hallmark of the market environment so far in 2022, with the S&P 500 still down more than 10% for the year-to-date after first sliding into a correction last month. The CBOE Volatility Index, or VIX, has held at a lofty level of more than 30. Channels are not fully encrypted, end-to-end. All communications on a Telegram channel can be seen by anyone on the channel and are also visible to Telegram. Telegram may be asked by a government to hand over the communications from a channel. Telegram has a history of standing up to Russian government requests for data, but how comfortable you are relying on that history to predict future behavior is up to you. Because Telegram has this data, it may also be stolen by hackers or leaked by an internal employee.
from sa
