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πŸ’‘ ΠžΡ†Π΅Π½ΠΈΠ»ΠΈ возмоТности использования Π³ΠΈΠ±Ρ€ΠΈΠ΄Π½Ρ‹Ρ… Π½Π°Π½ΠΎΠ²Π΅Π·ΠΈΠΊΡƒΠ» Π² качСствС систСмы доставки РНК 🎯

Π˜Π½Ρ‚Π΅Ρ€Π΅Ρ ΠΊ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Π°ΠΌ Π½Π° основС РНК растСт, Π½ΠΎ ΠΈΡ… использованиС ΠΎΠ³Ρ€Π°Π½ΠΈΡ‡Π΅Π½ΠΎ отсутствиСм Π΄Π°Π½Π½Ρ‹Ρ… ΠΏΠΎ бСзопасности ΠΈ эффСктивности систСм доставок πŸ“¦

πŸ«±πŸ»β€πŸ«²πŸΌ Π’ Π½Π΅Π΄Π°Π²Π½Π΅ΠΌ исслСдовании, Π²Π΄ΠΎΡ…Π½ΠΎΠ²Π»Π΅Π½Π½ΠΎΠΌ ΠΊΠΎΠ»Π»Π΅Π³Π°ΠΌΠΈ ΠΈΠ· БСчСновского унивСрситСта, УнивСрситСта Бириус, ΠœΠ“Π£ ΠΈΠΌ. М.Π’. Ломоносова, Научного Ρ†Π΅Π½Ρ‚Ρ€Π° исслСдований ΠΈ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ иммунобиологичСских ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΎΠ² ΠΈΠΌΠ΅Π½ΠΈ М.П. Π§ΡƒΠΌΠ°ΠΊΠΎΠ²Π° ΠΈ Π˜Π‘Π₯ РАН, ΠΌΡ‹ ΠΈΠ·ΡƒΡ‡ΠΈΠ»ΠΈ Π²Π½Π΅ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Π΅ Π½Π°Π½ΠΎΠ²Π΅Π·ΠΈΠΊΡƒΠ»Ρ‹ 🦠

Π‘Ρ‹Π»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, Ρ‡Ρ‚ΠΎ прСдлоТСнная Π² ΡΡ‚Π°Ρ‚ΡŒΠ΅ модификация наночастиц ΠΏΡ€ΠΈΠ²ΠΎΠ΄ΠΈΡ‚ ΠΊ Π±ΠΎΠ»Π΅Π΅ Ρ‡Π΅ΠΌ 10-ΠΊΡ€Π°Ρ‚Π½ΠΎΠΌΡƒ ΡƒΡΠΈΠ»Π΅Π½ΠΈΡŽ ΠΈΠ½Ρ‚Π΅Ρ€Π½Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ наночастиц in vitro ΠΈ Π±ΠΎΠ»Π΅Π΅, Ρ‡Π΅ΠΌ Π² 2 Ρ€Π°Π·Π° in vivo. Доставка РНК с использованиСм Π³ΠΈΠ±Ρ€ΠΈΠ΄ΠΎΠ² продСмонстрировала ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ >85% Π² ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Ρ… линиях Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΠΌΡ‹ΡˆΠΈ 🐁

πŸ“ƒ ΠŸΠΎΠ΄Ρ€ΠΎΠ±Π½Π΅Π΅ ΠΏΠΎΡ‡ΠΈΡ‚Π°Ρ‚ΡŒ ΠΌΠΎΠΆΠ½ΠΎ: https://doi.org/10.1016/j.ymthe.2024.11.004
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πŸ’‘ ΠžΡ†Π΅Π½ΠΈΠ»ΠΈ возмоТности использования Π³ΠΈΠ±Ρ€ΠΈΠ΄Π½Ρ‹Ρ… Π½Π°Π½ΠΎΠ²Π΅Π·ΠΈΠΊΡƒΠ» Π² качСствС систСмы доставки РНК 🎯

Π˜Π½Ρ‚Π΅Ρ€Π΅Ρ ΠΊ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Π°ΠΌ Π½Π° основС РНК растСт, Π½ΠΎ ΠΈΡ… использованиС ΠΎΠ³Ρ€Π°Π½ΠΈΡ‡Π΅Π½ΠΎ отсутствиСм Π΄Π°Π½Π½Ρ‹Ρ… ΠΏΠΎ бСзопасности ΠΈ эффСктивности систСм доставок πŸ“¦

πŸ«±πŸ»β€πŸ«²πŸΌ Π’ Π½Π΅Π΄Π°Π²Π½Π΅ΠΌ исслСдовании, Π²Π΄ΠΎΡ…Π½ΠΎΠ²Π»Π΅Π½Π½ΠΎΠΌ ΠΊΠΎΠ»Π»Π΅Π³Π°ΠΌΠΈ ΠΈΠ· БСчСновского унивСрситСта, УнивСрситСта Бириус, ΠœΠ“Π£ ΠΈΠΌ. М.Π’. Ломоносова, Научного Ρ†Π΅Π½Ρ‚Ρ€Π° исслСдований ΠΈ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ иммунобиологичСских ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΎΠ² ΠΈΠΌΠ΅Π½ΠΈ М.П. Π§ΡƒΠΌΠ°ΠΊΠΎΠ²Π° ΠΈ Π˜Π‘Π₯ РАН, ΠΌΡ‹ ΠΈΠ·ΡƒΡ‡ΠΈΠ»ΠΈ Π²Π½Π΅ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Π΅ Π½Π°Π½ΠΎΠ²Π΅Π·ΠΈΠΊΡƒΠ»Ρ‹ 🦠

Π‘Ρ‹Π»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, Ρ‡Ρ‚ΠΎ прСдлоТСнная Π² ΡΡ‚Π°Ρ‚ΡŒΠ΅ модификация наночастиц ΠΏΡ€ΠΈΠ²ΠΎΠ΄ΠΈΡ‚ ΠΊ Π±ΠΎΠ»Π΅Π΅ Ρ‡Π΅ΠΌ 10-ΠΊΡ€Π°Ρ‚Π½ΠΎΠΌΡƒ ΡƒΡΠΈΠ»Π΅Π½ΠΈΡŽ ΠΈΠ½Ρ‚Π΅Ρ€Π½Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ наночастиц in vitro ΠΈ Π±ΠΎΠ»Π΅Π΅, Ρ‡Π΅ΠΌ Π² 2 Ρ€Π°Π·Π° in vivo. Доставка РНК с использованиСм Π³ΠΈΠ±Ρ€ΠΈΠ΄ΠΎΠ² продСмонстрировала ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ >85% Π² ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½Ρ‹Ρ… линиях Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ ΠΌΡ‹ΡˆΠΈ 🐁

πŸ“ƒ ΠŸΠΎΠ΄Ρ€ΠΎΠ±Π½Π΅Π΅ ΠΏΠΎΡ‡ΠΈΡ‚Π°Ρ‚ΡŒ ΠΌΠΎΠΆΠ½ΠΎ: https://doi.org/10.1016/j.ymthe.2024.11.004

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The fake Zelenskiy account reached 20,000 followers on Telegram before it was shut down, a remedial action that experts say is all too rare. Telegram has become more interventionist over time, and has steadily increased its efforts to shut down these accounts. But this has also meant that the company has also engaged with lawmakers more generally, although it maintains that it doesn’t do so willingly. For instance, in September 2021, Telegram reportedly blocked a chat bot in support of (Putin critic) Alexei Navalny during Russia’s most recent parliamentary elections. Pavel Durov was quoted at the time saying that the company was obliged to follow a β€œlegitimate” law of the land. He added that as Apple and Google both follow the law, to violate it would give both platforms a reason to boot the messenger from its stores. In a statement, the regulator said the search and seizure operation was carried out against seven individuals and one corporate entity at multiple locations in Ahmedabad and Bhavnagar in Gujarat, Neemuch in Madhya Pradesh, Delhi, and Mumbai. Channels are not fully encrypted, end-to-end. All communications on a Telegram channel can be seen by anyone on the channel and are also visible to Telegram. Telegram may be asked by a government to hand over the communications from a channel. Telegram has a history of standing up to Russian government requests for data, but how comfortable you are relying on that history to predict future behavior is up to you. Because Telegram has this data, it may also be stolen by hackers or leaked by an internal employee. Founder Pavel Durov says tech is meant to set you free
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