Люблю истории, в которых белки меняют профессию. Давеча был описан еще один такой случай. Фермент биосинтеза пуринов de novo, IMPDH2, еще и ухитряется "подрабатывать" в клеточном ядре, регулируя репарацию ДНК! Связываясь с хроматином, он регулирует активность поли(АДФ)рибозополимеразы 1 (PARP1), контролируя уровень НАД+ — субстрата для PARP1. Без IMPDH2 в ядре начинают накапливаться мутации. В общем, личная эффективность IMPDH2 зашкаливает.
Люблю истории, в которых белки меняют профессию. Давеча был описан еще один такой случай. Фермент биосинтеза пуринов de novo, IMPDH2, еще и ухитряется "подрабатывать" в клеточном ядре, регулируя репарацию ДНК! Связываясь с хроматином, он регулирует активность поли(АДФ)рибозополимеразы 1 (PARP1), контролируя уровень НАД+ — субстрата для PARP1. Без IMPDH2 в ядре начинают накапливаться мутации. В общем, личная эффективность IMPDH2 зашкаливает.
Given the pro-privacy stance of the platform, it’s taken as a given that it’ll be used for a number of reasons, not all of them good. And Telegram has been attached to a fair few scandals related to terrorism, sexual exploitation and crime. Back in 2015, Vox described Telegram as “ISIS’ app of choice,” saying that the platform’s real use is the ability to use channels to distribute material to large groups at once. Telegram has acted to remove public channels affiliated with terrorism, but Pavel Durov reiterated that he had no business snooping on private conversations. But Kliuchnikov, the Ukranian now in France, said he will use Signal or WhatsApp for sensitive conversations, but questions around privacy on Telegram do not give him pause when it comes to sharing information about the war. Groups are also not fully encrypted, end-to-end. This includes private groups. Private groups cannot be seen by other Telegram users, but Telegram itself can see the groups and all of the communications that you have in them. All of the same risks and warnings about channels can be applied to groups. On Telegram’s website, it says that Pavel Durov “supports Telegram financially and ideologically while Nikolai (Duvov)’s input is technological.” Currently, the Telegram team is based in Dubai, having moved around from Berlin, London and Singapore after departing Russia. Meanwhile, the company which owns Telegram is registered in the British Virgin Islands. The fake Zelenskiy account reached 20,000 followers on Telegram before it was shut down, a remedial action that experts say is all too rare.
from tw
