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🔴 Oneway for Don't eat me signal is an interaction between CD47 and SIRPalpha. SIRP family has three different subtypes include Alpha, Beta, and Gamma.
🟠 In cancer cells interaction between SIRPalpha and CD inhibits macrophages to select cancer cells and macrophage phagocytosis and also this mechanism help cancer cells to evade the immunity.
🟡 Many studies shown that overexpression and higher levels of CD47 in tumor cells surface than non-malignant cells.
🟢 By exploiting the "Don't eat me" signal, cancer cells utilize CD47's overexpression to evade immune cell surveillance and clearance, making CD47 a potential target for novel anti-tumor therapies.
🔴 Oneway for Don't eat me signal is an interaction between CD47 and SIRPalpha. SIRP family has three different subtypes include Alpha, Beta, and Gamma.
🟠 In cancer cells interaction between SIRPalpha and CD inhibits macrophages to select cancer cells and macrophage phagocytosis and also this mechanism help cancer cells to evade the immunity.
🟡 Many studies shown that overexpression and higher levels of CD47 in tumor cells surface than non-malignant cells.
🟢 By exploiting the "Don't eat me" signal, cancer cells utilize CD47's overexpression to evade immune cell surveillance and clearance, making CD47 a potential target for novel anti-tumor therapies.
But the Ukraine Crisis Media Center's Tsekhanovska points out that communications are often down in zones most affected by the war, making this sort of cross-referencing a luxury many cannot afford. On Feb. 27, however, he admitted from his Russian-language account that "Telegram channels are increasingly becoming a source of unverified information related to Ukrainian events." In the United States, Telegram's lower public profile has helped it mostly avoid high level scrutiny from Congress, but it has not gone unnoticed. Andrey, a Russian entrepreneur living in Brazil who, fearing retaliation, asked that NPR not use his last name, said Telegram has become one of the few places Russians can access independent news about the war. "Markets were cheering this economic recovery and return to strong economic growth, but the cheers will turn to tears if the inflation outbreak pushes businesses and consumers to the brink of recession," he added.
from ua
