💥Breaking New Ground in Cancer Immunotherapy: CAR-Macrophages
🔴CAR-Macrophages (CAR-M) are engineered immune cells designed to target solid tumors by combining macrophages’ innate tumor-homing abilities with antigen-specific precision.
🟡 Unlike CAR-T cells, which struggle in dense tumor microenvironments (TME), CAR-Ms infiltrate tumors effectively, phagocytose cancer cells, and reprogram the TME to boost systemic immunity
🟣Mechanism of Action: Targeted Phagocytosis: CAR-Ms use chimeric antigen receptors (e.g., HER2, mesothelin) to recognize and engulf tumor cells
🟢TME Reprogramming: They secrete cytokines (IL-12, IFN-γ) to counteract immunosuppression and recruit T/NK cells via chemokines like CCL5
🟠Antigen Presentation: CAR-Ms process tumor antigens and activate T cells, bridging innate and adaptive immunity
🔵Structural Remodeling: Matrix metalloproteinases break down physical barriers in the TME, enhancing immune cell access
💥Breaking New Ground in Cancer Immunotherapy: CAR-Macrophages
🔴CAR-Macrophages (CAR-M) are engineered immune cells designed to target solid tumors by combining macrophages’ innate tumor-homing abilities with antigen-specific precision.
🟡 Unlike CAR-T cells, which struggle in dense tumor microenvironments (TME), CAR-Ms infiltrate tumors effectively, phagocytose cancer cells, and reprogram the TME to boost systemic immunity
🟣Mechanism of Action: Targeted Phagocytosis: CAR-Ms use chimeric antigen receptors (e.g., HER2, mesothelin) to recognize and engulf tumor cells
🟢TME Reprogramming: They secrete cytokines (IL-12, IFN-γ) to counteract immunosuppression and recruit T/NK cells via chemokines like CCL5
🟠Antigen Presentation: CAR-Ms process tumor antigens and activate T cells, bridging innate and adaptive immunity
🔵Structural Remodeling: Matrix metalloproteinases break down physical barriers in the TME, enhancing immune cell access
Individual messages can be fully encrypted. But the user has to turn on that function. It's not automatic, as it is on Signal and WhatsApp. In the United States, Telegram's lower public profile has helped it mostly avoid high level scrutiny from Congress, but it has not gone unnoticed. The perpetrators use various names to carry out the investment scams. They may also impersonate or clone licensed capital market intermediaries by using the names, logos, credentials, websites and other details of the legitimate entities to promote the illegal schemes. Update March 8, 2022: EFF has clarified that Channels and Groups are not fully encrypted, end-to-end, updated our post to link to Telegram’s FAQ for Cloud and Secret chats, updated to clarify that auto-delete is available for group and channel admins, and added some additional links. The news also helped traders look past another report showing decades-high inflation and shake off some of the volatility from recent sessions. The Bureau of Labor Statistics' February Consumer Price Index (CPI) this week showed another surge in prices even before Russia escalated its attacks in Ukraine. The headline CPI — soaring 7.9% over last year — underscored the sticky inflationary pressures reverberating across the U.S. economy, with everything from groceries to rents and airline fares getting more expensive for everyday consumers.
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