💥Breaking New Ground in Cancer Immunotherapy: CAR-Macrophages
🔴CAR-Macrophages (CAR-M) are engineered immune cells designed to target solid tumors by combining macrophages’ innate tumor-homing abilities with antigen-specific precision.
🟡 Unlike CAR-T cells, which struggle in dense tumor microenvironments (TME), CAR-Ms infiltrate tumors effectively, phagocytose cancer cells, and reprogram the TME to boost systemic immunity
🟣Mechanism of Action: Targeted Phagocytosis: CAR-Ms use chimeric antigen receptors (e.g., HER2, mesothelin) to recognize and engulf tumor cells
🟢TME Reprogramming: They secrete cytokines (IL-12, IFN-γ) to counteract immunosuppression and recruit T/NK cells via chemokines like CCL5
🟠Antigen Presentation: CAR-Ms process tumor antigens and activate T cells, bridging innate and adaptive immunity
🔵Structural Remodeling: Matrix metalloproteinases break down physical barriers in the TME, enhancing immune cell access
💥Breaking New Ground in Cancer Immunotherapy: CAR-Macrophages
🔴CAR-Macrophages (CAR-M) are engineered immune cells designed to target solid tumors by combining macrophages’ innate tumor-homing abilities with antigen-specific precision.
🟡 Unlike CAR-T cells, which struggle in dense tumor microenvironments (TME), CAR-Ms infiltrate tumors effectively, phagocytose cancer cells, and reprogram the TME to boost systemic immunity
🟣Mechanism of Action: Targeted Phagocytosis: CAR-Ms use chimeric antigen receptors (e.g., HER2, mesothelin) to recognize and engulf tumor cells
🟢TME Reprogramming: They secrete cytokines (IL-12, IFN-γ) to counteract immunosuppression and recruit T/NK cells via chemokines like CCL5
🟠Antigen Presentation: CAR-Ms process tumor antigens and activate T cells, bridging innate and adaptive immunity
🔵Structural Remodeling: Matrix metalloproteinases break down physical barriers in the TME, enhancing immune cell access
Individual messages can be fully encrypted. But the user has to turn on that function. It's not automatic, as it is on Signal and WhatsApp. "We're seeing really dramatic moves, and it's all really tied to Ukraine right now, and in a secondary way, in terms of interest rates," Octavio Marenzi, CEO of Opimas, told Yahoo Finance Live on Thursday. "This war in Ukraine is going to give the Fed the ammunition, the cover that it needs, to not raise interest rates too quickly. And I think Jay Powell is a very tepid sort of inflation fighter and he's not going to do as much as he needs to do to get that under control. And this seems like an excuse to kick the can further down the road still and not do too much too soon." On Telegram’s website, it says that Pavel Durov “supports Telegram financially and ideologically while Nikolai (Duvov)’s input is technological.” Currently, the Telegram team is based in Dubai, having moved around from Berlin, London and Singapore after departing Russia. Meanwhile, the company which owns Telegram is registered in the British Virgin Islands. In the United States, Telegram's lower public profile has helped it mostly avoid high level scrutiny from Congress, but it has not gone unnoticed. The next bit isn’t clear, but Durov reportedly claimed that his resignation, dated March 21st, was an April Fools’ prank. TechCrunch implies that it was a matter of principle, but it’s hard to be clear on the wheres, whos and whys. Similarly, on April 17th, the Moscow Times quoted Durov as saying that he quit the company after being pressured to reveal account details about Ukrainians protesting the then-president Viktor Yanukovych.
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